Fixed dose combination of ibuprofen and paracetamol induced toxic epidermal necrolysis

Ibuprofen induced Stevens-Johnson syndrome - toxic epidermal necrolysis in Nepal.

Despite the fact that any drug can be an impending cause of hypersensitivity reactions, Ibuprofen, an over-the-counter drug used extensively as an analgesic and antipyretic in Asia, is considered to be relatively safe. But herein we report a rare extremely 'rapid onset' occurrence of a severe case of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in a 22-year-old male, indu...

Ethambutol-induced toxic epidermal necrolysis.

continued. Four to fi ve days later patient again developed generalised body rashes with greater intensity for which she was referred to us. On examination she was febrile, vitals were stable, had erythematous patches over both malar prominences with haemorrhagic crusts present over the lips and anterior nares (Fig. 1), multiple areas of erosions all over the body with thick adherent yellow cru...

Phenytoin induced toxic epidermal necrolysis.

Toxic Epidermal Necrolysis (TEN) which is characterized by the detachment of the epidermis from the dermis is a rare (1.89/1.000.000 annually) and potentially life-threatening condition. The overall mortality is 20 - 30%. TEN is characterized by sudden apoptosis of keratinocytes leading to mucous membrane erosions and epidermal detachment; detachment of less than 10% of the total body surface a...

Carbamzepine-induced toxic epidermal necrolysis

Toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, is a widespread life-threatening mucocutaneous disease where there is extensive detachment of the skin and mucous membrane. Many factors involved in the etiology of TEN including adverse drug reactions. Here we are reporting a case of toxic epidermal necrolysis in an adult male patient after receiving carbamazepine in a 38 year o...

Nimesulide-induced hepatitis and toxic epidermal necrolysis.